Robert van Ling_Driving NanoLC-MS to its new cross-road - Are we heading towards highest sensitivity or increased throughput applications_Laborama 2020

Laborama 2020

Our Global Customer Success Manager, Robert van Ling will give a presentation at Laborama on Thursday 19 March 2020 at 11:45 am. Laborama will take place from 19 – 20 March at Brussels Expo Hall 1, Brussels, Belgium.

Driving NanoLC-MS to its new cross-road – Are we heading towards highest sensitivity or increased throughput applications?

With the µPAC™ technology, we are reaching new cross-roads for the chromatography of proteomic sample types. Utilizing the 200 cm, an excellent format for deep diving proteomics has become available, allowing the use of long and shallow gradients to push sensitivity and resolution for the identification of proteins and biomarkers further, in both data-dependent (DDA) and data-independent analysis (DIA). This is also valid for Single Cell Proteomics, and exciting field of proteomics research that is gaining more popularity today. With the minute protein content from a single cell, sensitivity and reproducibility are key conditions in LC-MS experiments.

However, another direction that is becoming more popular can be described as Clinical Proteomics. This is typically driven by large sample numbers, where gradients typically are 45 min or less. For these workflows, the µPAC™ technology can be run at the low µL/min range, and accommodate the typically used LC systems in this market.

In this presentation, we will address the capabilities of the µPAC™ technology, and also show examples of the applications mentioned above.

Find out more here.