Micro Pillar Array Column Technology Coupled to PASEF: A Sensitive Approach to Analyze Host Cell Proteins

Micro Pillar Array Column Technology Coupled to PASEF_A Sensitive Approach to Analyze Host Cell Proteins
Micro Pillar Array Column Technology Coupled to PASEF_A Sensitive Approach to Analyze Host Cell Proteins

Improve your detection of Host Cell Proteins (HCPs) in monoclonal antibody (mAB) preparations by implementing a workflow combination with 200cm µPAC™ C18 columns, parallel accumulation and serial fragmentation scans (PASEF) on the Bruker timsTOF Pro.

Conclusion

  • Comprehensive analysis of HCPs is obtained by using µPACTM nano LC columns in combination with PASEF technology.
  • 316 HCPs were identified in the NISTmAB reference material 8671, 91 of which with at least 3 peptide matches.

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