News and media

November 13, 2017

Webcast: An innovative nano-LC-MS approach for mAb and ADC characterization

In this webcast, Dr. Paul Jacobs of PharmaFluidics explains the principles and robustness of the micro-chip based pillar array columns. Dr. Koen Sandra of the Research Institute of Chromatography (RIC) demonstrates how micro pillar array columns, in combination with ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS), can be a very powerful tool to characterize mAbs and investigate the comparability between originator and biosimilar mAbs and to identify antibody-drug conjugation sites.
November 13, 2017

Webcast: A new LC approach to Complex Biological Samples

Watch this webcast to obtain first hand insight in the ins-and-outs of micro Pillar Array Chromatography (µPACᵀᴹ) columns from our COO, Dr. Paul Jacobs. He is joined by Dr. Koen Sandra, Scientific Director of the Research Institute of Chromatography, who demonstrates lipidomic profiling of human blood serum as an example case.
October 27, 2017

Gert Desmet named as #1 Separation Scientist and Leader of 2017

In The Analytical Scientist’s yearly power list, PharmaFluidics co-founder Gert Desmet was voted the most important Separation Scientist and Leader of 2017. Our Strategic Advisory Board member Pat Sandra joined him in the top 10. Congratulations to both!
October 9, 2017

PharmaFluidics and RIC present data on the comparison of biologicals and candidate biosimilars at BioProcess International 2017

At BioProcess International 2017 in Boston (USA), the results of a collaboration between the Research Institute for Chromatography and PharmaFluidics were presented. This poster gives an overview of the advantages of µPACTM columns in the characterization of monoclonal antibodies and antibody-drug conjugates (ADC).
October 9, 2017

PharmaFluidics and ThermoFisher present new proteomics results at HUPO2017

In collaboration with ThermoFisher, PharmaFluidics has presented new results on the benefits of µPAC in the analysis of small proteomic samples.
September 25, 2017

Characterizing antibody-drug conjugates using µPACTM-MS

The use of micro pillar array columns (μPACTM) for characterizing antibody-drug-conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analyzed. The resolving power offered by the μPACTM column allows an in-depth study of conjugation sites and accommodates the separation of isomeric conjugated peptides. In combination with all-ions MS/MS, conjugates peptides can selectively be recognized facilitating data interpretation.
September 25, 2017

Monoclonal antibody peptide mapping – Herceptine® originator and candidate biosimilar

The use of micro Pillar Array Columns (μPACTM) for monoclonal antibody (mAb) peptide mapping is presented. Herceptine® (trastuzumab) originator and candidate biosimilar tryptic digests were analyzed on a 200 cm μPACTM C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS). This way, post-translational modifications could be revealed. This makes μPACTM technology attractive to compare different mAb production batches and to compare mAb originator products to biosimilars.
September 25, 2017

Monoclonal antibody peptide mapping – Remicade® originator and candidate biosimilar

The use of micro Pillar Array Columns (μPACTM) for monoclonal antibody (mAb) peptide mapping is presented. Remicade® (infliximab) originator and candidate biosimilar tryptic digests were analyzed on a 200 cm μPACTM C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS). Minute differences such as point mutations in the protein sequence could be detected. μPACTM could thus be of great value in biosimilar characterization.
September 12, 2017

PharmaFluidics appoints Fasha Mahjoor as independent director

PharmaFluidics NV, an innovative player in the field of analytical chromatography products with the unique high-resolution µPACTM micro-Chip column, announced the appointment of Fasha Mahjoor as an independent director with effect as of September 6, 2017.
August 24, 2017

µPACᵀᴹ featured by the European Pharmaceutical Review at HPLC 2017

At the HPLC 2017 conference, the European Pharmaceutical Review sat down with the most innovative companies to find out first-hand what their technology is all about. PharmaFluidics was proud to be selected! Watch the interview with our VP Business Development and Sales, Katrien Vanhonacker, to find out more about µPACᵀᴹ and its applications.
June 28, 2017

Micro Pillar Array Columns (µPACTM) Combined with High-Resolution Mass Spectrometry for Skin Ceramide Profiling

Ceramides, a subclass of sphingolipids, are found in all tissues of the human body. The largest diversity is detected in human skin, more specifically in the uppermost layer of the epidermis, i.e. the stratum corneum, were ceramides play a prominent role in the barrier and permeability properties of the skin. Given the huge structural diversity, skin ceramide profiling requires the use of a highly efficient chromatographic step before mass spectrometric measurement. Micro pillar array columns (μPAC) are perfectly suited in that respect. Their unique benefits are illustrated in this application note.
June 28, 2017

Peptide separation on micro pillar array columns (µPACTM). Part 1: Cytochrome C tryptic digest

Reversed phase cytochrome c tryptic digest separations are routinely employed for the analysis/quality control of HPLC column performance towards proteomics applications. Easily detectable in UV and with few components, this sample proves to be an ideal tool in demonstrating column performance towards more complex digest separations requiring MS detection. The focus of this application note is to illustrate the performance and versatility of a 200 cm μPAC™ column for peptide separations.
June 27, 2017

Evaluation of Micro-Pillar Array Columns (µPAC) Combined with High Resolution Mass Spectrometry for Lipidomics

Obtaining insight in the structure and concentration of the wealth of lipids present in biological samples is of significant value in many areas, including biomarker discovery or drug discovery and development. However, this requires efficient separation techniques that can handle the varying physicochemical properties and dynamic range of compounds. In the HPLC 2017 Special issue of LCGC Europe, it is demonstrated how µPAC columns in combination with high-resolution mass spectrometry can tackle these challenges, using human blood plasma lipid samples.
June 24, 2017

Pat Sandra: LCGC’s 2017 Lifetime Achievement Award Winner

LCGC acknowledged our Strategic Advisory Board member's outstanding career with the 2017 Lifetime Achievement Award. In a recently published interview, Sandra recently spoke to LCGC about his career and work.
June 1, 2017

New Wave: Onward and upwards – exciting new paths lie ahead for LC

Koen Sandra, Scientific Director of the Research Institute for Chromatography (Kortrijk, Belgium) shed some light on his vision of the future of LC in the latest issue of The Analytical Scientist. We’re very proud that our µPAC® technology takes on a prominent role.
June 1, 2017

PharmaFluidics, Game-Changing Technology

PharmaFluidics helps pharmaceutical and life sciences companies identify new targets in complex biological samples. World Finance spoke to our Managing Director, Johan Devenyns, and co-founder Paul Jacobs to get insight on our µPAC® technology, its opportunities, and appealing business perspectives.
May 30, 2017

Pittcon 2017 New Products

Instrument Business Outlook included µPAC® columns in their summary of new products at Pittcon 2017!
May 30, 2017

PharmaFluidics raises funds for pillar array column R&D

A new article in Instrument News discusses the funding we have raised recently, how we will bring µPAC® columns to the market, and the short-term plans to expand production and develop future generations of Pillar Array Columns.
May 29, 2017

Separation Science at Pittcon 2017

Our µPAC® column was featured as one of the highlights in separation science at Pittcon 2017 by Labcompare, the buyer’s guide for laboratory equipment.
May 29, 2017

LCGC Europe – Annual Review of LC Columns and Accessories

PharmaFluidics' µPAC® technology was featured in the April issue of LCGC Europe!
May 23, 2017

PharmaFluidics present at the 18th Annual Bio€quity Europe

Bio€quity Europe is the collaborative gathering of corporate investment communities and financial dealmakers looking for investor-validated life science companies positioned to attract capital.
March 31, 2017

A new paradigm for proteomic and metabolomic profiling

PharmaFluidics' game-changing µPAC® technology was featured in this month's issue of Acquisition International. Great exposure for our company in the corporate finance community!
March 16, 2017

Pat Sandra receives Lifetime Achievement in Chromatography Award at Pittcon 2017

PharmaFluidics joined in to celebrate and thank our Strategic Advisory Board member for his guidance, insights and advice in preparing its micro-Chip based µPAC™ Pillar Array Chromatography columns for commercial launch.
March 14, 2017

Analytical performance of micro Pillar Array Columns (µPAC) for metabolic profiling

In this application note, plant extract samples are used to compare the analytical performance of a μPAC™ nano LC column to state-of-the-art UPLC columns. The combination of superior separation performance and increased detection sensitivity will enable analytical scientists to identify even more components in a single metabolic profiling run.
February 17, 2017

PharmaFluidics micro-Chips: Not for computers

Published on, February 2017 - The boundaries of technology can be pushed significantly when insights from different fields reinforce each other. A prime example is VUB spin-off PharmaFluidics. By combining expertise from the biotech and semiconductor chip manufacturing industries, this company initiates a paradigm shift in liquid chromatography (LC) separations.
January 17, 2017

PharmaFluidics raises 2.7 million euro to commercialize novel micro-chip device for Biomarker, Diagnostics and Drug development applications

Ghent, Belgium - January 17, 2017 - PharmaFluidics NV, a game-changing innovator in the field of analytical chromatography, announced today that it has raised 2.7 million euro of additional funding.
December 7, 2016

Curiosity driven chromatography

An interview with our co-founder and Director, Gert Desmet, was recently published in Mens & Molecule. In the article, he talks about his love for chromatography and how his PhD research has led to the inception of the ground-breaking separation technology of the PharmaFluidics µPACTM Pillar Array Columns.
December 6, 2016

Technical note 2: µPACTM performance in gradient separations

December 6, 2016

Technical note 1: perfect order promotes permeability