This column offers:

Increased separation performance

More than double the number of peptides and 72% more proteins identified in a 60 min analysis compared to a 15 cm packed bed column. Find out more in this technical note.

Improved coverage

The ultra-sensitive analysis of low-input proteomics samples enabled twice as many unique peptide and protein groups identifications compared to a traditional column. Discover the results in our webinar.

Extreme robustness

Each column has been manufactured by etching channels and pillar arrays out of a solid silicon wafer. The column is perfectly bidirectional and contains no particles or frits. This prevents blockages and retention time variation over multiple runs. Run your entire project on a single column.

Increased column to column reproducibility

Each column is manufactured using the same lithographic mask, making every column identical. Replace µPACᵀᴹs with minimal impact. Obtain results over time and across laboratories, sufficiently consistent for big data analysis.

High flow rate flexibility

The column can be operated at moderate LC pump pressures up to 350 bar over a wide range of flow rates (100 – 2,000 nL/min). The maximum operating pressure is 350 bar.

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Technical note 8_µPAC™ LC, a new era in column-to-column reproducibility
Technical notes

Technical note 8: µPAC™ LC, a new era in column-to-column reproducibility

µPAC™ LC, a new era in column-to-column reproducibility The main goal of this study is to compare the column-to-column reproducibility of the μPAC™ capLC column …

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Webinar

Watch our webinar on demand – Double your IDs for single cell proteomics using micro Pillar Array Columns (µPAC™)

This webinar will explore the potential of newly emerging chromatographic technologies to significantly improve sensitivity for low input proteomics samples, as well as providing detailed …

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Publications

Routine Proteome Analysis Using 50 cm micro Pillar Array Columns – GEN

According to PharmaFluidics, more sample components can be identified if separation channels are etched in silicon. The practice of bottom-up proteomics relies to a large …

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Interview_Dr. Duncan Smith_ Robustness and repeatability - The promise of μPAC™in low flow LCMS
Publications

Duncan Smith – Robustness and repeatability The promise of μPAC™ in low flow LCMS

Interview with Dr. Duncan Smith, Cancer Research UK (CRUK) Manchester Institute. Within Cancer Research UK Manchester Institute, Dr. Smith is Head of Mass Spectrometry, responsible …

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