Technical note 7: Assessment of capillary flow HPLC column performance

Assessment of capillary flow HPLC column performance

In this technical note, the performance of PharmaFluidics µPAC™ capLC columns is compared to the current state-of-the-art in commercial capillary flow LC columns. The advantages for capillary flow reversed phase liquid chromatography analyses is discussed based on experimentally derived chromatographic parameters such as column pressure, retention factor and efficiency in both isocratic and gradient separation mode. Owing to their superior permeability and theoretical plate numbers, µPAC™ capLC columns are shown to outperform commercial capillary flow HPLC columns over the entire range between 1 to 10 µL/min.

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